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Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
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Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

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The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

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The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

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Microfluidic technologies for circulating tumor cell isolation.

Hyungseok Cho1, Jinho Kim, Hanjung Song

  • 1Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae 621-749, Republic of Korea. mems@inje.ac.kr.

The Analyst
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Early detection of circulating tumor cells (CTCs) is crucial for cancer prognosis. Advanced microfluidic technologies offer promising methods for isolating and analyzing these vital cells for improved patient outcomes.

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Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model
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Area of Science:

  • Oncology
  • Biotechnology
  • Medical Diagnostics

Background:

  • Metastasis, driven by circulating tumor cells (CTCs), is a primary cause of cancer mortality.
  • Early detection and analysis of CTCs are essential for timely diagnosis, prognosis, and effective cancer treatment.
  • Microfluidic technologies have emerged as powerful tools for CTC isolation and detection.

Purpose of the Study:

  • To review current advanced microfluidic technologies for CTC isolation.
  • To discuss the advantages and limitations of these methods for downstream assays.
  • To explore single-cell isolation techniques and future microfluidic platform innovations.

Main Methods:

  • Review of microfluidic technologies based on biological and physical principles.
  • Analysis of methods for isolating individual CTCs, addressing genetic heterogeneity.
  • Discussion of strategies to overcome current limitations in CTC isolation.

Main Results:

  • Microfluidic technologies show significant potential for CTC isolation and detection.
  • Various microfluidic approaches leverage different biological and physical properties.
  • Single-cell isolation methods are advancing to address CTC heterogeneity.

Conclusions:

  • Microfluidic technologies are vital for advancing CTC analysis in cancer diagnostics.
  • Further innovation in microfluidic platforms is needed to overcome existing limitations.
  • Improved CTC isolation and analysis promise better clinical outcomes for cancer patients.