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Updated: Feb 10, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
FeCl3 or MeSO3H-promoted multicomponent reactions for facile synthesis of structurally diverse furan analogues
Xiangqing Chang1, Xiongfei Zhang, Zhiwei Chen
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology; College of Pharmaceutical Sciences, Zhejiang University of Technology, Chao Wang Road 18th, 310014, Hangzhou, China. chenzhiwei@zjut.edu.cn.
Abstract:
An intriguing conversion of arylglyoxal, cyclic dicarbonyl compounds and phenols to diverse furan analogues under FeCl3 or MeSO3H catalysis is reported. Utilizing this synthetic protocol, a variety of furan analogues could be easily obtained in moderate to good yields with different substituted patterns by varying the reaction medium. Atom-economical characteristics and mild conditions of this method are in accord with the concept of modern green chemistry.
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