Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study
Marta Gormicho Boavida Marques Esgalhado1, Milena Barcza Stockler-Pinto1, Ludmila Ferreira Medeiros de França Cardozo1
1Universidade Federal Fluminense, Programa de Pós-Graduação em Ciências Cardiovasculares Niterói, Rio de Janeiro (RJ), Brasil.
Jornal Brasileiro De Nefrologia
|May 26, 2018
Summary
High-intensity exercise did not increase irisin hormone levels in hemodialysis patients. Irisin plasma levels were found to decrease after one hour of dialysis, regardless of exercise.
Area of Science:
- Endocrinology
- Exercise Physiology
- Nephrology
Background:
- Irisin is an exercise-induced hormone linked to fat tissue browning.
- Irisin regulation and exercise effects in chronic kidney disease (CKD) patients are poorly understood.
Purpose of the Study:
- To investigate the impact of high-intensity exercise on irisin plasma levels in CKD patients undergoing hemodialysis (HD).
Main Methods:
- Fifteen HD patients performed a 30-minute intradialytic strength exercise session.
- Blood samples were collected pre- and post-dialysis on exercise and non-exercise days.
- Plasma irisin levels were quantified using ELISA.
Main Results:
- Irisin levels significantly decreased after 60 minutes of dialysis on both exercise and non-exercise days.
- Intradialytic strength exercise did not lead to an increase in plasma irisin concentrations.
Conclusions:
- Intense intradialytic strength exercise failed to elevate circulating irisin in HD patients.
- Dialysis sessions may be associated with a reduction in plasma irisin levels.
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