Related Experiment Video
Updated: Feb 10, 2026
05:18
Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
Published on: January 16, 2026
60
Does cognition improve following LVAD implantation?
Marykay A Pavol1, Joshua Z Willey2, Ying Wei3
1Stroke Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA. mp2740@cumc.columbia.edu.
General Thoracic and Cardiovascular Surgery
|May 26, 2018
Summary
Cognition significantly improved 3 months after left ventricular assist device (LVAD) surgery, but not at 1 month. These findings suggest delayed cognitive recovery in LVAD patients without stroke.
Area of Science:
- Cardiology
- Neuroscience
- Medical Devices
Background:
- Cognitive function post-LVAD surgery shows variable outcomes.
- Previous studies yielded mixed results on cognitive changes after LVAD implantation.
- Exclusion of patients with post-surgical stroke allows for focused analysis.
Purpose of the Study:
- To investigate cognitive changes at 1 and 3 months after LVAD surgery.
- To determine if cognition improves, declines, or remains stable post-LVAD.
- To assess cognitive trajectories in patients undergoing LVAD implantation.
Main Methods:
- Observational case series of 28 patients from the DuraHeart LVAS device trial.
- Cognitive assessments conducted at baseline, 1-month, and 3-month post-surgery.
- Tests included attention, memory, language, visual-motor speed (TMT), and visual construction.
Main Results:
- No significant cognitive difference was observed between baseline and 1-month post-surgery.
- Cognition significantly improved from baseline to 3-month post-surgery (p < 0.00001).
- Trail Making Test (TMT) scores were the only significantly different individual test at 3 months.
Conclusions:
- Significant cognitive enhancement occurs 3 months post-LVAD surgery in patients without stroke.
- Delayed cognitive improvement may be attributed to immediate post-operative physiological disruptions.
- Cognitive assessments shortly after surgery require cautious interpretation; longer-term outcomes may differ.
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