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Related Experiment Videos

Does Caved-S decrease the gastric ulcer relapse rate during maintenance treatment with ranitidine?

A G Morgan1, C Pacsoo, P Taylor

  • 1Endoscopy Unit, Airedale General Hospital, Steeton, Keighley, UK.

Alimentary Pharmacology & Therapeutics
|December 1, 1987
PubMed
Summary
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This study found that adding Caved-S to ranitidine did not significantly reduce gastric ulcer recurrence in elderly patients. Long-term maintenance therapy is recommended for life to prevent symptomatic ulcer recurrence.

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Background:

  • Gastric ulcers pose a significant health concern, particularly in elderly populations.
  • Maintenance therapy is often employed to prevent ulcer recurrence after initial healing.

Purpose of the Study:

  • To evaluate the efficacy of combined ranitidine and Caved-S therapy versus ranitidine alone for preventing gastric ulcer recurrence.
  • To assess the long-term outcomes and patient tolerability of maintenance therapy for healed gastric ulcers.

Main Methods:

  • A 2-year randomized controlled trial involving 95 patients with healed gastric ulcers.
  • Patients received ranitidine 150 mg at night plus either Caved-S (two tablets twice daily) or a placebo.
  • Recurrence rates were monitored annually, with a 3-month follow-up after treatment cessation.

Related Experiment Videos

Main Results:

  • After 1 year, recurrence rates were 12.5% for ranitidine alone and 19% for combination therapy (not significant).
  • After 2 years, recurrence rates were 30% for ranitidine alone and 40% for combination therapy (not significant).
  • 11% of patients experienced symptomatic recurrence within 3 months of stopping maintenance therapy.

Conclusions:

  • Combined ranitidine and Caved-S therapy offers no significant clinical advantage over ranitidine alone for preventing gastric ulcer recurrence.
  • Combination therapy was associated with poor patient tolerability.
  • Lifelong maintenance therapy is recommended for elderly patients with a history of gastric ulceration to prevent recurrence.