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Updated: Feb 10, 2026
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Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
Published on: May 26, 2013
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Comparative genomic analysis of Myroides odoratimimus isolates
Shaohua Hu1, Lin Cao2, Yiyin Wu3
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
Microbiologyopen
|May 26, 2018
Summary
Myroides odoratimimus, a difficult-to-treat nosocomial pathogen, shares similar genome structures and virulence factors across clinical and environmental strains. This comparative genomics study aids in understanding its antibiotic resistance and pathogenesis.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Myroides odoratimimus is a significant nosocomial pathogen.
- Managing M. odoratimimus infections is challenging due to multidrug resistance and unclear pathogenesis.
- Previous genomic data of M. odoratimimus PR63039 prompted further investigation.
Purpose of the Study:
- To conduct a comparative genomic analysis of 10 Myroides strains.
- To identify genetic elements contributing to genome evolution, antibiotic resistance, and virulence.
- To elucidate potential pathogenesis mechanisms of M. odoratimimus infections.
Main Methods:
- Comparative genomic analysis of 10 Myroides strains.
- Identification of prophages and CRISPR elements.
- Analysis of antibiotic resistance genes using CARD.
- Speculation on the presence and role of virulence factors (VFs).
Main Results:
- Myroides strains exhibited highly similar genome contexts and phylogenetic relatedness.
- Prophages were identified in clinical isolates, suggesting a role in genome evolution.
- Antibiotic resistance gene profiles were similar among clinical strains.
- Clinical and environmental strains likely possess similar virulence factors involved in pathogenesis, dissemination, and autoimmune complications.
Conclusions:
- Comparative genomics reveals conserved genetic features in Myroides strains.
- Understanding shared virulence factors and resistance genes is crucial for developing effective therapeutic strategies.
- This research supports the development of novel treatments for M. odoratimimus infections.
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