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Impact of Early-Life Weight Status on Cognitive Abilities in Children
Nan Li1, Kimberly Yolton2, Bruce P Lanphear3
1Department of Epidemiology, Brown University, Providence, Rhode Island, USA.
Insights
Early childhood obesity may negatively impact cognitive development. Higher weight status in early life was linked to lower scores in perceptual reasoning, working memory, and potentially overall intelligence in children.
Area of Science:
- Pediatric Health
- Neurodevelopmental Science
- Obesity Research
Background:
- The relationship between childhood obesity and cognitive development remains under-explored.
- The developing brain is particularly vulnerable to environmental influences, including nutritional status.
Purpose of the Study:
- To investigate the association between early-life weight status and cognitive function in children.
- To determine if weight-for-height standard deviation scores in early childhood predict later cognitive abilities.
Main Methods:
- Utilized data from the HOME Study (2003-2006) involving mother-child pairs.
- Assessed early-life weight status using weight-for-length/height standard deviation (SD) scores.
- Administered neuropsychological tests at ages 5 and 8 to evaluate cognition, executive function, and visual-spatial abilities.
Main Results:
- A 1-unit increase in weight-for-height SD score was associated with a decrease in full-scale IQ scores (β = -1.4).
- Perceptual reasoning (β = -1.7) and working memory (β = -2.4) scores also decreased with increased weight-for-height SD.
- No significant associations were found between weight status and other cognitive measures.
Conclusions:
- Early-life weight status is inversely associated with perceptual reasoning and working memory in children.
- Findings suggest a potential link between early-life weight status and full-scale intelligent quotient scores.
Objective:
Whether obesity is associated with childhood cognition is unknown. Given the sensitivity of the developing brain to environmental factors, this study examined whether early-life weight status was associated with children's cognition.
Methods:
Using data from mother-child pairs enrolled in the Health Outcomes and Measures of the Environment (HOME) Study (2003-2006), children's early-life weight status was assessed using weight-for-length/height standard deviation (SD) scores. A battery of neuropsychological tests was administered to assess cognition, executive function, and visual-spatial abilities at ages 5 and 8 years. Using linear mixed models, associations between early-life weight status and cognition were estimated.
Results:
Among 233 children, 167 were lean (≤1 SD) and 48 were nonlean (>1 SD). After covariate adjustment, the results suggest that full-scale intelligence quotient scores decreased with a 1-unit increase in weight-for-height SD score (β = -1.4, 95% CI: -3.0 to 0.1). For individual component scores, with a 1-unit increase in weight-for-height SD score, perceptual reasoning (β = -1.7, 95% CI: -3.3 to 0.0) and working memory (β: -2.4, CI: -4.4 to -0.4) scores decreased. Weight status was generally not associated with other cognition measures.
Conclusions:
Within this cohort of typically developing children, early-life weight status was inversely associated with children's perceptual reasoning and working memory scores and possibly with full-scale intelligent quotient scores.
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