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A Mouse Model of Fatigue Induced by Peripheral Irradiation
Published on: March 17, 2017
Sudden spinal hemorrhage in a pediatric case with total body irradiation-induced cavernous hemangioma
Takashi Mikami1, Itaru Kato1, Fumihito Nozaki2
1Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract:
Compared to cerebral radiation-induced cavernous hemangiomas (RICHs), little is known about intraspinal RICHs. A 13-year-old male suddenly developed symptomatic spinal hemorrhage eight years after hematopoietic stem cell transplantation using a total body irradiation (TBI) based myeloablative regimen. A solitary small hemangioma was detected on follow-up T2 star weighted magnetic resonance imaging of the spine. His neurological symptoms gradually improved with supportive treatment and rehabilitation, although he experienced rebleeding 2 years later. Intraspinal RICH is very rare but should be recognized as a possible late adverse effect in pediatric patients who received TBI.
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