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Noncoding RNAs as therapeutic targets in atherosclerosis with diabetes mellitus

Ningning Tang1, Shaoyan Jiang2, Yanyan Yang1

  • 1Institute for Translational Medicine, Qingdao University, Qingdao, China.

Cardiovascular Therapeutics
|May 26, 2018
PubMed

Insights

Noncoding RNAs (ncRNAs) are crucial in managing diabetes mellitus (DM)-associated atherosclerosis by regulating key cells. Research highlights ncRNAs as promising therapeutic targets and biomarkers for this complex condition.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Atherosclerosis is a primary cause of death in diabetes mellitus (DM) patients.
  • Endothelial cells, vascular smooth muscle cells (VSMCs), and macrophages are key players in DM-associated atherosclerosis.
  • Targeting these cells is a critical therapeutic strategy.

Purpose of the Study:

  • To review the regulatory roles of noncoding RNAs (ncRNAs) in DM-associated atherosclerosis.
  • To explore ncRNAs as potential therapeutic targets and biomarkers for this condition.

Main Methods:

  • Literature review of recent research on ncRNAs in DM and atherosclerosis.
  • Analysis of studies involving ncRNAs in cellular responses and pathological processes.
  • Examination of preclinical and clinical trial data on ncRNA efficacy.

Main Results:

  • Noncoding RNAs (ncRNAs) significantly influence cellular processes in DM-associated atherosclerosis.
  • Evidence suggests ncRNAs can drive atherogenic or antiatherogenic mechanisms.
  • Numerous ncRNAs show promise in animal models and clinical trials.

Conclusions:

  • Noncoding RNAs (ncRNAs) are vital regulators in diabetes mellitus (DM)-associated atherosclerosis.
  • ncRNAs represent promising therapeutic targets and biomarkers for managing DM-associated atherosclerosis.
  • Further research into ncRNA mechanisms can lead to novel treatment strategies.
Keywords:
biomarkerscardiovasculardiabetes mellitusnoncoding RNAstargets

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