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Tandem Mass Spectrometry01:21

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Rapid Quantitative Analysis of Multiple Explosive Compound Classes on a Single Instrument via Flow-Injection Analysis

Alla Ostrinskaya1, Roderick R Kunz1, Michelle Clark1

  • 1Chemical, Microsystem, and Nanoscale Technology Group, MIT-Lincoln Laboratory, 244 Wood Street, Lexington, MA, 02421.

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A new flow-injection analysis tandem mass spectrometry (FIA MSMS) method enables rapid, sensitive detection of 10 explosives. This technique offers precise trace explosive analysis for forensics and security.

Keywords:
HMTDHMXRDXTATPTNTFIA APCI/ESI MSMSPC tetrylforensic science

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Area of Science:

  • Analytical Chemistry
  • Forensic Science

Background:

  • Trace explosive detection is critical for national security and forensic investigations.
  • Existing methods may lack the speed, sensitivity, or comprehensive analyte coverage required for certain applications.

Purpose of the Study:

  • To develop and validate a rapid, sensitive, and precise method for the quantitative analysis of multiple explosives.
  • To optimize a flow-injection analysis tandem mass spectrometry (FIA MSMS) technique for trace explosive detection.

Main Methods:

  • Development of a flow-injection analysis tandem mass spectrometry (FIA MSMS) method.
  • Optimization of ionization (APCI/ESI), de-clustering potentials, and collision energies for 10 target analytes.
  • Quantitative analysis of urea nitrate, potassium chlorate, TNT, RDX, TATP, HMTD, PETN, RALT, NG, and HMX.

Main Results:

  • The FIA MSMS method achieved high sensitivity, with limits of quantification (LOQ) in the picogram per milliliter range for all 10 explosives.
  • Analysis time per sample was rapid, typically less than one minute.
  • The method demonstrated good precision, with intraday relative standard deviations (RSD) below 10%.

Conclusions:

  • FIA MSMS is a fast, sensitive, and precise method suitable for trace explosive detection.
  • This technique has significant potential applications in criminal forensics, attributional forensics, counterterrorism, and environmental protection.
  • The developed method could potentially replace or enhance existing explosive detection technologies.