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Vertebrate lectins and their possible role in fertilization, development and tumor biology (review)

H J Gabius1

  • 1Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Göttingen, F.R.G.

In Vivo (Athens, Greece)
|March 1, 1987
PubMed

Agglutination of cells is not only a functional test, employed in lectin characterization: the ability of lectins to mediate intercellular contacts may have physiological relevance beyond the test tube. Selected examples of advances in research on vertebrate lectins underscore their potential physiological significance in fertilization, development and in the pathogenesis of cancer.

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...