[Relationship among airway infection, lung function damage and the tumor recurrence in patients with laryngeal...

Objective:To investigate the relationship among airway infection, lung function damage and the tumor recurrence in patients with laryngeal cancer.Method:Eighty-six patients with laryngeal cancer were retrospectively analyzed.Infection rate were compared between different surgical airway and operation time, the lung function damage and the tumor recurrence were analysed.Result:Total laryngectomy group joint cervix lymph node dissection showed higher airway infection rate than laryngectomy［32.5%（13/40）vs 4.3%（2/46）,P <0.05］. Significant differences were observed among operation time＜4 h, 4-6 h,＞6 h airway infection rate is statistically ［2.5%(1/40),19.4%(6/31),53.3%(8/15), P <0.05］; Infection rate was positively correlated with the trachea and the operation time(r=0.41P <0.01). Significant rise in FEV1% and reduce in V25 were observed after operation(P <0.05). No statistical difference were observed in patients with airway infected or uninfected with tumor recurrence and uninfected group is ［13.3% (2/15)vs 9.9%(7/71)，P > 0.05］.Conclusion:Throat cut method may lead to airway infection and impairment of the lung function, but airway infection has no obvious effect in tumor recurrence.