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Published on: September 8, 2015
[Expression and clinical significance of HIF-1α in laryngeal carcinoma]
1Department of Interventional Radiography, Suizhou Hospital,Hubei University of Medicine, Suizhou, 441300, China.
Abstract:
Objective:To investigate the expression and clinical significance of HIF-1α in laryngeal carcinoma(LC). Method:Databases including PubMed, EMbase, Web of Science, VIP, CNKI and Wan-Fang Data were searched from 2000.1 to 2015.12, and all relevant references were also retrieved to collect relevant case-control studies. The included studies were screened according to the exclusion criteria. Then the meta-analysis was conducted by RevMan 5.3 software. Result:A total of 5 case-control studies involving 202 LC tissues and 75 normal laryngeal tissues were included. The results of the meta-analyses showed that, as for the positive rate of HIF-1α expression, it was higher in LC tissues than that in normal esophageal tissues [OR=22.4,95%CI (9.79,51.25),P<0.01], in LC tissues with lymph node metastasis than in that without lymph node metastasis [OR=7.10,95%CI (3.10, 16.30), P<0.01], in moderate and low differentiated LC tissues than those in high differentiated LC tissues[OR=4.40, 95%CI (2.28, 8.49), P<0.01].The expression of HIF-1α in clinical stage Ⅲ-Ⅳ was significantly higher than that in clinical stage Ⅰ-Ⅱ[OR=5.89, 95%CI (2.44, 14.24), P<0.01]. Conclusion:The present limited evidence shows that the HIF-1α expression is associated with LC, lymph node metastasis, degree of cell differentiation and clinical stage of LC, indicating that LC may take a role in the whole course of carcinogenesis of LC. Further well-designed and high quality case-control studies are needed to prove the results.
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