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Effects of multiple administration of halothane on the mixed function oxidase system in liver microsomes. Difference
1Division of Dental Anesthesia, Hiroshima University Dental Hospital, Japan.
In Vivo (Athens, Greece)
|November 1, 1987
Abstract:
The effects of multiple administration of halothane on the mixed function oxidase system in liver microsomes were investigated and compared between guinea pigs and rats to clarify the difference in sensitivity to halothane. The mixed function oxidase system, except for NADPH-cytochrome P-450 recductase activity was increased in both animals. The inhibition in guinea pigs may have resulted from the microsomal membrane damage induced by the acceleration of lipid peroxidation.