[Risk factors of papillary thyroid carcinoma in different ages of young patients]

Objective:To investigate the clinical characteristics of the risk factors of papillary thyroid carcinoma in different ages of young patients (<45y)associated with carbon nanoparticles.Method:A retrospective statistics and analysis of 183 patients who were diagnosed and treated; carbon nanoparticles were injected into the thyroid during operation and at last the conventional pathological diagnosis were papillary thyroid carcinoma of all patients; to analysis the gender, tumor size, capsular invasion, lymph node metastasis, multifocality and other risk factors between the <25y and 25-<5y patients.Result:The parathyroid were better identified, while the central lymph nodes better turned black after carbon nanoparticles injected; <25y compared to 25-<45y in the tumor size, multifocality, capsular invasion, extrathyroidal extension, associated with Hashimoto Thyroiditis, the differences had statistical significant(P<0.01 or P<0.05).In young (<45y) thyroid papillary carcinoma, preoperative serum thyroglobulin level was beyond the normal range, indicating a large possibility of lateral neck lymph node metastasized, but the two age groups had no statistical significant(P>0.05) in serum thyroglobulin and thyroid stimulating hormone.Conclusion:Carbon nanoparticles can effectively recognize parathyroid and trace central lymph nodes. In the <25y groups, the tumor diameter is more likely to exceed 1cm, the lateral neck nodes are more easily metastasized, capsular invasion and extrathyroidal extension are also more easily to turn up. While the 25-<45y groups are more likely to form multifocality, which may be accompanied by Hashimoto Thyroiditis and prone to occur central lymph nodes metastasized. In the younger patients (<45y), the more preoperative serum thyroglobulin higher, the more probable lateral neck nodes metastasized.