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[Correlation between TLR4 gene polymorphisms and allergic rhinitis].

S He1, J Chen1

  • 1Department of Otolaryngology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Genetic variations in the Toll-like receptor 4 (TLR4) locus are linked to allergic rhinitis (AR) susceptibility. Specifically, the rs10759930 polymorphism significantly increases the risk of developing AR.

Keywords:
single nucleotide polymorphismToll-like receptorrhinitis, allergic

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Area of Science:

  • Immunogenetics
  • Allergology
  • Molecular Biology

Background:

  • Allergic rhinitis (AR) is a prevalent allergic disease with a complex etiology.
  • Genetic factors play a significant role in AR susceptibility.
  • Toll-like receptor 4 (TLR4) is involved in immune responses and has been implicated in allergic diseases.

Purpose of the Study:

  • To investigate the association between polymorphisms in the TLR4 gene locus and the risk of developing allergic rhinitis.
  • To analyze the correlation between specific TLR4 gene variations and AR susceptibility in a case-control study.

Main Methods:

  • Genotyping of three TLR4 locus polymorphisms (rs10759930, rs2737190, rs2770150) using PCR sequencing.
  • Comparison of genotype and allele frequencies between 212 allergic rhinitis patients and 169 healthy controls.
  • Statistical analysis using SPSS version 17.0 to determine genetic associations.

Main Results:

  • The rs10759930 polymorphism showed a significant association with allergic rhinitis.
  • Both heterozygous (CT) and homozygous (TT) genotypes at rs10759930 were significantly linked to increased AR risk (P < 10⁻⁶).
  • Odds ratios indicated a substantial increase in AR susceptibility for individuals with CT (OR=2.66) and TT (OR=8.78) genotypes.

Conclusions:

  • The rs10759930 polymorphism in the TLR4 locus is a significant genetic risk factor for allergic rhinitis.
  • Both heterozygous and homozygous alleles at rs10759930 are associated with increased susceptibility to allergic rhinitis.
  • These findings contribute to understanding the genetic basis of allergic rhinitis and potential immunogenetic targets.