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Updated: Feb 10, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
[The standardization of inflammation detecting methods in upper and lower airways]
1Department of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Abstract:
Objective:To investigate the standardization of inflammation detecting methods in upper and lower airways. Method:After a five year cooperation with Guangzhou Institute of Respiratory Diseases on inflammatory diseases of airways, we have found a series of evaluation methodology and normative values in upper and lower airways (NO), airway hyper reactivity and cytology (Eos). Result:The normative range of nasal and pulmonary NO is 400-900 ppb and 5-25 ppb respectively. The nasal resistance increased ≥100% and FEV1 fell ≥20% when compared with their respective baselines both illustrating a positive result. The positive value of nasal and pulmonary Eos are ≥2.00/HP and ≥2.5% respectively. Conclusion:The standardization of evaluation methods for upper and lower airway inflammation provides the methodology and research basis for follow-up studies of upper and lower airways.
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