Related Experiment Video
Updated: Feb 10, 2026

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
[Regulation of microRNA-17-92 cluster on bone development, remodeling, and metabolism]
1Laboratory of Endocrinology and Metabolism, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Objective:
To review the regulation of microRNA-17-92 cluster on bone development, remodeling, and metabolism.
Methods:
The related literature was reviewed. The clinical genetic phenotype, animal experiment, and cell research were illustrated so as to explore the possible regulatory mechanisms.
Results:
MicroRNA-17-92 cluster is involved in physiological normal organs development, pathological neoplasm occurrence, and development. Recently, studies have shown that microRNA-17-92 cluster constitutes an intricate molecular signaling network with its upstream transcription factors and downstream targeting proteins, which controls bone development, remodeling, and metabolism exquisitely.
Conclusion:
Present fundamental researches have certain understanding of the regulatory mechanisms of microRNA-17-92 cluster on bone development, remodeling, and metabolism. However, the exact mechanisms under these processes remain unknown.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
MicroRNAs
MicroRNAs
Regulation of Metabolism
Nucleosome Remodeling
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...

