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Increased plasma complement factor H is associated with geriatric depression

Cheolmin Shin1, Byung-Joo Ham1, Young-Hoon Ko1

  • 1Department of Psychiatry,College of Medicine,Korea University,Seoul,Republic of Korea.

International Psychogeriatrics
|May 26, 2018
PubMed

Insights

Elderly individuals with depression show higher plasma levels of complement factor H (CFH). This suggests the complement system

Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Complement factor H (CFH) regulates the complement system's alternative pathway.
  • Dysregulation of CFH is implicated in inflammation-mediated diseases, including neuropsychiatric disorders.

Purpose of the Study:

  • To investigate the association between plasma CFH levels and geriatric depression.
  • To determine if CFH levels differ in elderly individuals with and without depression.

Main Methods:

  • 152 elderly individuals (76 with MDD, 76 controls) were analyzed.
  • Plasma CFH levels were measured and compared between groups.
  • Multiple regression analysis adjusted for confounders was performed.

Main Results:

  • Plasma CFH levels were significantly higher in the MDD group compared to controls (p < 0.001).
  • CFH was significantly associated with geriatric depression after adjusting for confounders (p < 0.001).

Conclusions:

  • Elevated plasma CFH levels are associated with geriatric depression.
  • This suggests the complement system's alternative pathway may contribute to geriatric depression development.

Keywords:
alternative pathwaycomplement factor Hcomplement systemgeriatric depression

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