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Related Experiment Video

Updated: Feb 10, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Increased plasma complement factor H is associated with geriatric depression.

Cheolmin Shin¹, Byung-Joo Ham¹, Young-Hoon Ko¹

¹Department of Psychiatry,College of Medicine,Korea University,Seoul,Republic of Korea.

International Psychogeriatrics

|May 26, 2018

Summary

This summary is machine-generated.

Elderly individuals with depression show higher plasma levels of complement factor H (CFH). This suggests the complement system

Keywords:

alternative pathway complement factor H complement system geriatric depression

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Last Updated: Feb 10, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: September 9, 2012

Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet

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Published on: November 2, 2020

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Published on: April 28, 2016

Area of Science:

Neuroscience
Immunology
Gerontology

Background:

Complement factor H (CFH) regulates the complement system's alternative pathway.
Dysregulation of CFH is implicated in inflammation-mediated diseases, including neuropsychiatric disorders.

Purpose of the Study:

To investigate the association between plasma CFH levels and geriatric depression.
To determine if CFH levels differ in elderly individuals with and without depression.

Main Methods:

152 elderly individuals (76 with MDD, 76 controls) were analyzed.
Plasma CFH levels were measured and compared between groups.
Multiple regression analysis adjusted for confounders was performed.

Main Results:

Plasma CFH levels were significantly higher in the MDD group compared to controls (p < 0.001).
CFH was significantly associated with geriatric depression after adjusting for confounders (p < 0.001).

Conclusions:

Elevated plasma CFH levels are associated with geriatric depression.
This suggests the complement system's alternative pathway may contribute to geriatric depression development.