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Antiplatelet Therapy, Cerebral Microbleeds, and Intracerebral Hemorrhage: A Meta-Analysis

Jianting Qiu1, Huirong Ye1, Jialiang Wang1

  • 1From the Department of Neurology, Cerebrovascular Disease Center, People's Hospital, China Medical University, Shenyang, People's Republic of China.

Stroke
|May 26, 2018
PubMed
Abstract

Insights

Antiplatelet therapy increases the risk of strictly lobar cerebral microbleeds (CMBs). This therapy also elevates the incidence of intracerebral hemorrhage in patients with CMBs.

Area of Science:

  • Neurology
  • Cardiovascular Research
  • Clinical Trials

Background:

  • Cerebral microbleeds (CMBs) are small hemorrhages in the brain.
  • The association between antiplatelet therapy and CMBs requires further investigation.
  • Differentiating effects on lobar versus deep/infratentorial CMBs is crucial.

Purpose of the Study:

  • To investigate the association between antiplatelet therapy and cerebral microbleeds (CMBs).
  • To analyze the differential impact of antiplatelet agents on strictly lobar versus deep/infratentorial CMBs.
  • To assess the risk of intracerebral hemorrhage in antiplatelet users with CMBs.

Main Methods:

  • Systematic review and meta-analysis of studies from PubMed and EMBASE (1997-2017).
  • Pooled odds ratios (OR) calculated for CMB incidence and distribution.
  • OR calculated for intracerebral hemorrhage incidence in antiplatelet users with and without CMBs.

Main Results:

  • Included 37 studies with 20,988 participants.
  • CMBs were more frequent in antiplatelet users (OR, 1.21).
  • Significant association between antiplatelet therapy and strictly lobar CMBs (OR, 1.45).
  • Higher intracerebral hemorrhage incidence in antiplatelet users with CMBs (OR, 3.40).

Conclusions:

  • Antiplatelet drug use is linked to an increased risk of strictly lobar CMBs.
  • Antiplatelet therapy elevates intracerebral hemorrhage risk in individuals with CMBs.
Keywords:
hemosiderinincidencemagnetic resonance imagingmeta-analysisrisk

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