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A frequency distribution table can be constructed using the steps given below.
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Metabolic Labeling and Profiling of Transfer RNAs Using Macroarrays
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A simple technique to construct tissue macroarrays.

Eliane P Dias1, Bruna L S Picciani1, Vanessa de C B Dos Santos1

  • 1Postgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niteroi, Brazil.

Journal of Clinical Pathology
|May 26, 2018
PubMed
Summary

This study introduces tissue macroarrays (TMaAs) as a cost-effective method to improve histopathological analysis. TMaAs offer a solution to the limitations of tissue microarrays (TMAs) by using larger tissue fragments for more representative results.

Keywords:
analytical methodshistopathologyimmunohistochemistrylaboratory managementmicro array

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Area of Science:

  • Histopathology
  • Biotechnology
  • Oncology Research

Background:

  • Tissue microarrays (TMAs) accelerate in situ studies but have limitations in representing whole tissue characteristics due to small core sizes.
  • A need exists for cost-effective and time-efficient histopathological evaluation methods in diagnostic and research settings.

Purpose of the Study:

  • To present a simple system for constructing tissue macroarrays (TMaAs).
  • To detail the technical aspects, advantages, and limitations of the TMaA method.
  • To demonstrate the utility of TMaAs in research applications.

Main Methods:

  • The study describes a method for preparing specimens up to 6 mm in diameter for inclusion in TMaA paraffin blocks.
  • Three preparation possibilities are presented for TMaA construction.

Main Results:

  • The TMaA technique successfully produced glass slides containing multiple whole tissue fragments.
  • These slides were utilized in five distinct research studies, demonstrating the method's applicability.

Conclusions:

  • A straightforward method for constructing multi-TMaA paraffin blocks has been developed.
  • This technique optimizes laboratory workflows for paraffin-embedded tissue sections and is easily implementable in any histology laboratory.