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Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
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Related Experiment Video

Updated: Feb 10, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Epigenomes in Cardiovascular Disease.

Manuel Rosa-Garrido¹, Douglas J Chapski¹, Thomas M Vondriska²

¹From the Departments of Anesthesiology, Medicine, and Physiology, David Geffen School of Medicine, University of California, Los Angeles.

Circulation Research

|May 26, 2018

Summary

This summary is machine-generated.

Unifying principles of how genomes create diverse cells and integrate genetic and environmental factors for cardiovascular health are emerging. Understanding epigenomic landscapes and chromatin function is key to new cardiovascular disease therapies.

Keywords:

cardiovascular diseases chromatin epigenomics genetics transcriptome

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Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Area of Science:

Cell Biology
Genetics
Cardiovascular Medicine

Background:

The genome encodes diverse eukaryotic cells through complex regulatory mechanisms.
Cardiovascular health is influenced by genetic variability and environmental factors.
Epigenetic factors like chromatin modifiers and noncoding RNAs play roles in cardiovascular disease.

Purpose of the Study:

To explore the conceptual framework for studying epigenomes.
To discuss how chromatin function principles can advance cardiovascular disease research.
To stimulate dialogue on developing novel cardiovascular therapies.

Main Methods:

Utilizing epigenomic tools and next-generation sequencing.
Analyzing cardiovascular models and human populations.
Reviewing existing literature on chromatin-modifying enzymes and transcriptome-shaping factors.

Main Results:

Epigenomic landscapes underpinning cardiovascular cellular function have been described.
Key molecular players in cardiovascular health and disease have been identified.
The integration of genetic and environmental influences on cardiovascular health is being elucidated.

Conclusions:

Understanding epigenomes is crucial for dissecting cardiovascular disease mechanisms.
Principles of chromatin function offer a framework for therapeutic development.
Further research integrating epigenomics and chromatin biology can advance cardiovascular medicine.