Related Experiment Video
Updated: Feb 10, 2026

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
Published on: November 7, 2015
Targeted Therapies for Brain Tumors: Will They Ever Deliver?
1Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio. vogelbm@ccf.org.
Abstract:
The strategy of using biologically targeted therapeutics for cancer has yet to translate into effective treatment of gliomas. The neuro-oncology community is beginning to recognize that phase 0 studies should be performed to account for the impact of the blood-brain barrier on the ability of a therapeutic to reach its target(s). Clin Cancer Res; 24(16); 3790-1. ©2018 AACRSee related article by Sanai et al., p. 3820.
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