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[A role of microRNA in the pathogenesis of ischemic stroke]

L B Novikova1, G M Minibaeva1

  • 1Bashkir State Medical University, Ufa, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|May 26, 2018
PubMed

Insights

Cardioembolic stroke, a major cause of ischemic stroke, is linked to cardiac issues like atrial fibrillation. MicroRNAs are emerging as key regulators and potential biomarkers for ischemic stroke diagnosis and prognosis.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Ischemic stroke (IS) is a primary cause of global mortality and disability.
  • Cardioembolic stroke (CEI) constitutes up to 40% of all IS cases.
  • Non-rheumatic atrial fibrillation is the predominant cause of CEI.

Purpose of the Study:

  • To review current understanding of cardiac disease roles in CEI pathogenesis.
  • To explore the significance of microRNAs in IS pathogenesis.
  • To highlight microRNAs as potential diagnostic and prognostic biomarkers for IS.

Main Methods:

  • Literature review of existing studies on IS, CEI, cardiac diseases, and microRNAs.
  • Analysis of genetic factors and regulatory mechanisms in IS.
  • Synthesis of current knowledge on microRNA function and biomarker potential.

Main Results:

  • Cardiac diseases, particularly atrial fibrillation, are central to CEI development.
  • MicroRNAs, as gene expression regulators, are implicated in IS pathogenesis.
  • MicroRNAs demonstrate potential for simultaneous regulation of multiple genes.

Conclusions:

  • MicroRNAs represent a significant area of research for understanding IS.
  • MicroRNAs show promise as novel diagnostic and prognostic biomarkers for ischemic stroke.
  • Further research into microRNAs could lead to improved IS management strategies.

Keywords:
biomarkerscardioembolic strokeischemic strokemicroRNA

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