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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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[MicroRNA in ischemic stroke]

K A Aitbaev1, I T Murkamilov2, V V Fomin3

  • 1Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|May 26, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key gene regulators offering potential for stroke diagnosis and therapy. Understanding their role in stroke pathophysiology is crucial for improving patient outcomes and developing new treatments.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Stroke is a leading cause of disability worldwide, necessitating improved diagnostic and therapeutic strategies.
  • Current understanding of stroke pathophysiology requires advancement for better patient outcomes.
  • MicroRNAs (miRNAs) represent a novel class of gene regulators with therapeutic and diagnostic potential.

Purpose of the Study:

  • To review the role of miRNAs in experimental stroke models.
  • To explore the involvement of miRNAs in carotid artery stroke development.
  • To discuss the potential of miRNAs as biomarkers for stroke.

Main Methods:

  • Literature review of studies on miRNA regulation in stroke.
  • Analysis of experimental stroke models and carotid artery stroke development.
  • Evaluation of miRNA as potential stroke biomarkers.

Main Results:

  • MiRNAs play a significant role in regulating gene expression relevant to stroke.
  • Specific miRNAs are implicated in the pathophysiology of experimental and carotid artery stroke.
  • MiRNAs show promise as sensitive and specific biomarkers for stroke detection.

Conclusions:

  • MicroRNAs are critical regulators in stroke pathophysiology.
  • Targeting miRNAs offers a potential therapeutic avenue for stroke.
  • MiRNAs hold significant promise as biomarkers for improved stroke diagnosis and management.
Keywords:
biomarkerscerebrovascular diseasesmicroRNAsecondary preventionstroke

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