Related Experiment Video

Updated: Feb 10, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.5K

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Jiaqi Tang1, Cody C Gifford2, Rohan Samarakoon3

  • 1Department of Regenerative and Cancer Cell Biology, Albany Medical Center, 47 New Scotland Avenue, Albany, NY 12208, USA. tangj2@amc.edu.

Cancers
|May 26, 2018
PubMed

Insights

Transforming growth factor-β1 (TGF-β1) initially inhibits cancer but later promotes it. Restoring its negative regulators may offer new cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Transforming growth factor-β1 (TGF-β1) exhibits dual roles in cancer, inhibiting early growth but promoting late-stage progression and metastasis.
  • Aberrant TGF-β1 signaling is critical in fibrotic and neoplastic disorders, necessitating multi-level negative controls.

Purpose of the Study:

  • To review the negative regulators of the TGF-β1 pathway and their impact on cancer.
  • To explore the therapeutic potential of restoring these endogenous repressors for cancer treatment.

Main Methods:

  • Literature review of TGF-β1 signaling network and its negative regulators.
  • Analysis of how dysregulation of repressors contributes to cancer progression, metastasis, and cellular plasticity.

Main Results:

  • Negative regulators like PTEN, PPM1A, Klotho, BMP7, SMAD7, Ski/SnoN, and BAMBI control TGF-β1 signaling at multiple levels.
  • Loss, overexpression, mutation, or deletion of these repressors during cancer progression alters TGF-β1 signal duration/intensity, promoting tumor aggressiveness.

Conclusions:

  • Aberrant regulation of TGF-β1 negative regulators drives cellular plasticity, tumor progression, metastasis, and resistance to cell cycle arrest.
  • Restoring the expression and/or function of these endogenous repressors presents a promising, yet unexplored, therapeutic strategy for cancer treatment.
Keywords:
BAMBIBMP7KlothoPPM1APTENSMAD7Ski/Snocellular plasticitytransforming growth factor-β1tumor progression

More Related Videos

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System11:06

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Published on: July 30, 2018

11.1K
Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis10:56

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

8.8K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
617