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Updated: Feb 10, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Epstein Barr Virus-Associated Hodgkin Lymphoma

Antonino Carbone1, Annunziata Gloghini2

  • 1Department of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via F. Gallini 2, 33081 Aviano, Italy. acarbone@cro.it.

Cancers
|May 26, 2018
PubMed

Abstract: Classical Hodgkin lymphoma (cHL) is a distinct clinical and pathological entity with heterogeneous genetic and virological features, with regards to Epstein⁻Barr virus (EBV) infection. The variable association of cHL with EBV infection is probably related to the different levels of patient immunosuppression, both locally in the tumour tissue and at the systemic level. This review paper focuses on EBV-related cHL highlighting pathogenetic and pathological features that may impact pathobiology-driven treatment for the affected patients.

Keywords:
Epstein-Barr virusHodgkin lymphomaimmunosuppressiontumour microenvironment

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