Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-surface Signaling01:21

Cell-surface Signaling

54.6K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.6K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

27.5K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.5K
Ribosome Profiling02:24

Ribosome Profiling

4.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
Surface Tension and Surface Energy01:16

Surface Tension and Surface Energy

3.3K
When a paint brush is immersed in water, the bristles wave freely inside the water. When it is taken out, the bristles stick together. The reason behind this effect is surface tension.
Consider a beaker filled with liquid. The bulk molecules in the liquid experience equal attractive forces on all sides with the surrounding molecules. However, the surface molecules experience a net attractive force downward due to the bulk molecules. The surface of the liquid behaves like a stretched membrane,...
3.3K
Frustration and Conflict: Approach-Approach, Approach-Avoidance01:20

Frustration and Conflict: Approach-Approach, Approach-Avoidance

540
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
540
Wood Surfacing01:14

Wood Surfacing

364
Wood surfacing is a critical finishing process designed to smoothen the wood surface, enhance its dimensional accuracy, and make handling safer. This process compensates for potential shrinkage during the seasoning phase by marginally increasing the wood dimensions before surfacing. It also helps correct some distortions that may occur as the wood dries.
The equipment used in the surfacing process is a plane equipped with rotating blades. This tool efficiently smoothens the wood surface and can...
364

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraepithelial T cells and tumor-associated macrophages in ovarian cancer patients.

Cancer immunity·2013
Same author

Research on 2D representation method of wireless Micro-Ball endoscopic images.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
Same author

Photocatalytic properties of graphdiyne and graphene modified TiOâ‚‚: from theory to experiment.

ACS nano·2013
Same author

Relationship between the structures of flavonoids and oxygen radical absorbance capacity values: a quantum chemical analysis.

The journal of physical chemistry. A·2013
Same author

[Early diagnosis and treatment of acute mesentric ischemia for 42 cases in single center].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2013
Same author

Periodontitis as a novel contributor of adipose tissue inflammation promotes insulin resistance in a rat model.

Journal of periodontology·2013
Same journal

Cell Surface Glycans: From Recognition Technologies and Functional Editing to Medical Applications.

Glycobiology·2026
Same journal

Aberrant O-glycosylation genes and miR-21-5p targets define a molecular signature of tumor aggressiveness in triple-negative breast cancer.

Glycobiology·2026
Same journal

Cancer-Associated Alterations In O-GalNAc Glycosylation.

Glycobiology·2026
Same journal

Glyco you should know.

Glycobiology·2026
Same journal

Biosynthesis of human milk oligosaccharides (HMOs) in glycoengineered human cells.

Glycobiology·2026
Same journal

Glyco you should know.

Glycobiology·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

14.4K

Recent approaches for directly profiling cell surface sialoform.

Xiaoqing Zhang1, Huan Nie1, Joshua Whited2

  • 1School of Life Science and Technology, Harbin Institute of Technology, 2 Yikuang-jie, Harbin, Heilongjiang, China.

Glycobiology
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Sialic acids (SAs) on cell surfaces are crucial biomarkers. This review details advanced bioaffinity methods for detecting and profiling these sialic acid structures, aiding disease diagnostics and therapeutics.

More Related Videos

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

15.4K
Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
08:07

Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques

Published on: January 12, 2024

1.3K

Related Experiment Videos

Last Updated: Feb 10, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

14.4K
Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

15.4K
Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
08:07

Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques

Published on: January 12, 2024

1.3K

Area of Science:

  • Biochemistry
  • Glycobiology
  • Cell Biology

Background:

  • Sialic acids (SAs) are terminal monosaccharides on cell surface glycans.
  • Cell surface sialoforms (SA expression and linkages) are key indicators of cellular states.
  • Profiling sialoforms is vital for understanding biological processes and disease mechanisms.

Purpose of the Study:

  • To review recent bioaffinity approaches for detecting and profiling specific sialic acids and sialylglycans.
  • To highlight advancements in experimental materials and analytical technologies for sialoform analysis.

Main Methods:

  • Development of SA-specific binding molecules.
  • Application of techniques including fluorescent imaging, flow cytometry, and microarrays.
  • Analysis of sialoforms on various cell and tissue types.

Main Results:

  • Bioaffinity methods enable direct detection and profiling of specific sialoforms.
  • Technological advancements have expanded analysis from frozen tissues to living cells.
  • SA profiling offers potential for therapeutic and diagnostic applications.

Conclusions:

  • Advanced bioaffinity techniques are essential for detailed sialoform analysis.
  • Understanding sialoforms contributes to diagnostics and therapeutics for various diseases.
  • Continued research in SA detection methods promises further biomedical applications.