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Bioprostheses at twelve years.

N Spampinato1, P Stassano, A Cammarota

  • 1Department of Cardiac Surgery, 2nd Medical School, University of Naples, Italy.

Journal of Cardiac Surgery
|September 1, 1988
PubMed
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This study compared seven bioprostheses implanted between 1976-1986. Most tissue valve prostheses showed similar long-term durability, with only a few exhibiting early failure.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Medical Device Engineering

Background:

  • Bioprosthetic heart valves are crucial for treating valvular heart disease.
  • Understanding the long-term performance of different bioprostheses is essential for clinical decision-making.
  • A variety of tissue valve prostheses were available and implanted during the study period.

Purpose of the Study:

  • To compare the long-term durability and failure rates of seven different types of bioprosthetic heart valves.
  • To identify any significant differences in performance among the evaluated bioprostheses.
  • To provide data on the cumulative probability of being free from tissue valve failure (TVF).

Main Methods:

  • A retrospective analysis of 1,414 bioprostheses implanted in 1,098 patients from January 1976 to December 1986.

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  • Follow-up data collected over 1 to 12 years, with a cumulative duration of 6,747 patient-years.
  • Actuarial probability calculations were used to determine freedom from tissue valve failure (TVF) for each bioprosthesis type.

    • Main Results:

    • Overall cumulative actuarial probability of being free from TVF was 85.1% at 10 years and 61.6% at 12 years.
    • Most bioprostheses demonstrated similar long-term performance.
    • Specific valves like Hancock, Liotta, and Vascor showed lower probabilities of being free from TVF at earlier time points compared to others.

    Conclusions:

    • The study indicates that most bioprosthetic heart valves implanted during the study period exhibit comparable long-term durability.
    • A small subset of bioprostheses demonstrated a trend of earlier negative outcomes.
    • These findings contribute to the understanding of bioprosthetic valve performance and longevity.