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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

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The expanding roles of microRNAs in kidney pathophysiology

Valérie Metzinger-Le Meuth1, Ophélie Fourdinier2, Nathalie Charnaux1

  • 1INSERM U1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, Université Paris 13, Bobigny, France.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|May 26, 2018
PubMed

Insights

MicroRNAs (miRNAs) show promise as biomarkers for kidney diseases. Further research is needed to standardize measurement and explore miRNA-based therapies for kidney and cardiovascular conditions.

Area of Science:

  • Molecular Biology
  • Nephrology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • miRNAs play a crucial role in kidney physiopathology.
  • Their involvement spans various kidney disease models and patient groups.

Purpose of the Study:

  • To review the role of miRNAs in kidney diseases.
  • To discuss their potential as biomarkers in nephrology.
  • To explore innovative miRNA-based therapeutic strategies.

Main Methods:

  • Literature review of miRNA involvement in kidney disease.
  • Analysis of miRNA roles in cellular and animal models.
  • Examination of miRNA implications in patient cohorts (CKD, AKI, hemodialysis, transplant).

Main Results:

  • miRNAs are implicated in diverse kidney disease contexts.
  • Current evidence suggests miRNAs as potential diagnostic and prognostic biomarkers.
  • Challenges include cohort size and method standardization for clinical utility.

Conclusions:

  • miRNAs hold significant potential as biomarkers in nephrology.
  • Standardization of measurement and selection of appropriate biofluids are critical.
  • Targeted modulation of deregulated miRNAs offers innovative therapeutic avenues for kidney and related organ damage.

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