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Updated: Feb 10, 2026
Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Recent advances in flavonoid-grafted polysaccharides: Synthesis, structural characterization, bioactivities and
Jun Liu1, Xingchi Wang1, Huimin Yong1
1College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, Jiangsu, China.
Abstract:
Plant derived flavonoids have been demonstrated to possess many valuable biological functions. In recent years, flavonoids have been successfully conjugated with polysaccharides through different graft copolymerization methods including chemical coupling, enzyme catalysis, free radical mediated grafting, and acid catalyzed condensation reactions. The successful grafting of flavonoids onto polysaccharides can be confirmed by several instrumental methods. The conjugation of flavonoids can significantly improve the antioxidant, antimicrobial, antitumor, hepatoprotective and enzyme inhibition properties of polysaccharides. Moreover, the applications of polysaccharides in food and pharmaceutical industries can be greatly broadened by grafting with flavonoids. Flavonoid-grafted polysaccharides can be developed as films for active packaging, hydrogels for controlled drug release, micelles for oral drug delivery, and emulsions for nutraceutical delivery. In general, the bioactivities and applications of conjugates are closely related to the type of flavonoid grafted, the grafting method used as well as the grafting efficiency. Recent advances in the synthesis, structural characterization, bioactivities and potential applications of flavonoid-grafted polysaccharides are summarized in this review.
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