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PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice

Xie Jun1, Geng Jin2, Chen Fu1

  • 1Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 26, 2018
PubMed
Abstract

Insights

Exposure to fine particulate matter (PM2.5) significantly promotes abdominal aortic aneurysm (AAA) development in mice. This may be linked to PM2.5-induced cellular senescence, highlighting a new cardiovascular risk factor.

Area of Science:

  • Environmental Health
  • Cardiovascular Research
  • Toxicology

Background:

  • Particulate matter 2.5 (PM2.5) is linked to cardiovascular disease mortality.
  • The role of PM2.5 in abdominal aortic aneurysm (AAA) formation is not well understood.

Purpose of the Study:

  • To investigate the association between PM2.5 exposure and the development of AAA.
  • To elucidate the potential mechanisms underlying PM2.5-induced AAA.

Main Methods:

  • Angiotensin II-infused apolipoprotein E-deficient mice were exposed to PM2.5 or saline via intranasal instillation.
  • Histological and immunohistological analyses were performed to assess AAA formation and related markers.
  • Human aortic smooth muscle cells (HASMCs) were used for in vitro mechanistic studies.

Main Results:

  • PM2.5 exposure significantly increased AAA incidence, aortic diameter, and elastin degradation.
  • PM2.5 enhanced the expression of senescence markers (P21, P16), MMP2, MCP-1, and reactive oxygen species in vitro.
  • Cellular senescence was identified as a potential mechanism in PM2.5-induced AAA.

Conclusions:

  • PM2.5 promotes AAA formation in a mouse model.
  • Cellular senescence induced by PM2.5 exposure is a likely underlying mechanism for AAA development.
Keywords:
Abdominal aortic aneurysmAir pollutionPM2.5SenescenceSmooth muscle cell

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