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Updated: Feb 10, 2026
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Association between heavy metal levels and acute ischemic stroke.
Ching-Huang Lin1,2,3, Yi-Ting Hsu1,2, Cheng-Chung Yen2
1Department of Biological Sciences, National Sun Yet-Sen University, Kaohsiung, Taiwan.
Journal of Biomedical Science
|May 27, 2018
Summary
This study found lower mercury levels in patients with acute ischemic stroke (AIS). These findings suggest a potential link between heavy metal dysregulation and stroke incidence.
Area of Science:
- Environmental Health
- Neurology
- Toxicology
Background:
- Limited research exists on the connection between heavy metal exposure and stroke incidence.
- Investigating heavy metals like lead (Pb), mercury (Hg), arsenic (As), and cadmium (Cd) in acute ischemic stroke (AIS) patients is crucial.
Purpose of the Study:
- To explore the relationship between serum and urine heavy metal levels and the occurrence of first-ever acute ischemic stroke (AIS).
Main Methods:
- Serum and urine heavy metal levels (Pb, Hg, As, Cd) were measured in 33 AIS patients and 39 healthy controls.
- Urine samples were collected 24 hours post-infusion of edetate calcium disodium (EDTA) to assess heavy metal excretion.
Main Results:
- AIS patients exhibited significantly lower serum and urine mercury (Hg) levels compared to healthy controls.
- No significant differences were found in serum or urine levels of lead (Pb), arsenic (As), or cadmium (Cd) between the groups.
Conclusions:
- The study identified lower serum and urine Hg levels in patients with first-ever AIS.
- This suggests a potential dysregulation of heavy metals, specifically mercury, in the context of AIS.
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