Related Experiment Video
Updated: Feb 10, 2026

04:48
Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
Published on: April 18, 2025
1.1K
JACIE: A 20 year-old voluntary body functioning worldwide
Meltem Kurt Yüksel1, Osman İlhan1
1Ankara University, School of Medicine Hematology, Department and Bone Marrow Transplantation Unit, Turkey.
Summary
Hematopoietic Stem Cell Transplantation (HSCT) quality improved with the establishment of standards. The Joint Accreditation Committee of ISCT-EBMT (JACIE) has guided this progress globally and in Turkey for twenty years.
Area of Science:
- Hematology
- Immunotherapy
- Cellular Therapy
Background:
- Hematopoietic Stem Cell Transplantation (HSCT) is a critical treatment for severe blood disorders, pioneered in 1957.
- While HSCT numbers have risen globally, quality improvement has lagged behind volume increases.
- The European Group for Bone Marrow Transplantation (EBMT) and SHAGE Europe established initial standards in 1998.
Purpose of the Study:
- To review the aims and twenty-year history of the Joint Accreditation Committee of ISCT-EBMT (JACIE).
- To highlight JACIE's role in improving HSCT quality worldwide and specifically in Turkey.
- To inform stakeholders, including patients, about JACIE's contributions to HSCT standards.
Main Methods:
- Review of historical data and establishment of HSCT standards.
- Analysis of JACIE's organizational development and impact over two decades.
- Examination of JACIE's implementation and history in Turkey.
Main Results:
- JACIE was founded to enhance HSCT quality and patient safety.
- The organization has played a vital role in standardizing cell collection, processing, and transplantation.
- Significant progress in HSCT quality has been observed over the past twenty years due to JACIE's efforts.
Conclusions:
- JACIE is essential for maintaining and improving HSCT standards globally.
- The committee's work benefits all stakeholders, particularly patients undergoing HSCT.
- The review underscores the importance of accreditation in advancing cellular therapies.
Related Concept Videos
Body Temperature
4.9K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
4.9K
Body Temperature
1.5K
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
1.5K
Centroid of a Body
1.9K
The centroid is an important concept in engineering, physics, and mechanics. It is the geometric center of a body. It always lies within the body except in cases with holes or cavities. When the material that a body is composed of is uniform or homogeneous, the centroid coincides with its center of mass or the center of gravity.
For a homogeneous body with constant density, the centroid can usually be found using equations representing a balance of the moments of the body's volume. If the...
For a homogeneous body with constant density, the centroid can usually be found using equations representing a balance of the moments of the body's volume. If the...
1.9K
Free-body Diagram
3.7K
In mechanics, understanding the motion of objects is essential, and one tool that helps solve this problem is the free-body diagram. It is a simple but powerful graphical representation that succinctly represents all the forces acting on an object. A free-body diagram can represent a stationary or moving object, and is used in mechanics to explain the cause of an object's motion.
A free-body diagram transforms a complex problem into a simple representation, making it easy to understand the...
A free-body diagram transforms a complex problem into a simple representation, making it easy to understand the...
3.7K
Composite Bodies
1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
Whole Body Regeneration
4.2K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.2K

