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Related Experiment Video

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Chronic PFOS Exposure Disrupts Thyroid Structure and Function in Zebrafish.

Jiangfei Chen1, Lidan Zheng1, Linjie Tian1

  • 1Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou, 325035, China.

Bulletin of Environmental Contamination and Toxicology
|May 27, 2018
PubMed
Summary

Chronic exposure to Perfluorooctane sulfonic acid (PFOS) in zebrafish altered thyroid hormone levels and thyroid structure. Zebrafish serve as a viable model for assessing PFOS chronic toxicity and its endocrine-disrupting effects.

Keywords:
Gene expressionPFOSThyroid hormoneThyroid morphologyZebrafish

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Area of Science:

  • Environmental toxicology
  • Endocrinology
  • Aquatic toxicology

Background:

  • Perfluorooctane sulfonic acid (PFOS) is a widespread environmental contaminant with potential endocrine-disrupting properties.
  • Limited research exists on the chronic effects of PFOS on thyroid function in aquatic organisms and their underlying mechanisms.

Purpose of the Study:

  • To investigate the impact of chronic PFOS exposure on thyroid structure and function in zebrafish.
  • To evaluate thyroid hormone levels, morphology, and gene expression related to thyroid function in zebrafish exposed to PFOS.

Main Methods:

  • Zebrafish were exposed to 250 µg/l PFOS from 8 hours post fertilization (hpf) to 120 days post fertilization (dpf).
  • Thyroid hormone levels (T3 and T4), thyroid morphology, and the expression of thyroid function-related genes were assessed at 120 dpf.

Main Results:

  • Chronic PFOS exposure led to significant alterations in thyroid hormone levels (T3 and T4) in zebrafish.
  • Changes in thyroid follicular cell structure and thyroid hormone-related gene expression were observed.
  • PFOS exposure demonstrated an impact on thyroid morphology and function.

Conclusions:

  • Chronic PFOS exposure adversely affects thyroid structure and function in zebrafish.
  • Zebrafish are a suitable model for evaluating the chronic toxicity of PFOS, particularly its endocrine-disrupting effects on the thyroid.
  • Findings highlight the need for further investigation into PFOS toxicity mechanisms in aquatic wildlife.