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The factors associated with successful early enteral feeding in gastroschisis
Theerayuth Pratheeppanyapat1, Kanokkan Tepmalai1, Jesda Singhavejsakul1
1Division of Pediatric Surgery, Department of Surgery, Chiang Mai University Hospital, 110 Intavaroros Road, Muang Chiang Mai District, Chiang Mai, 50200, Thailand.
Insights
Successful early enteral feeding in gastroschisis is linked to factors like female sex, later gestational age, and prompt surgery. Modifiable factors include early surgery, extubation, and feeding initiation to improve outcomes.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Congenital Abnormalities
Background:
- Gastroschisis is a common congenital abdominal wall defect.
- Delayed bowel function recovery is frequent due to midgut exposure to amniotic fluid.
Purpose of the Study:
- Identify factors associated with successful early enteral feeding in gastroschisis.
- Develop improved treatment guidelines for gastroschisis management.
Main Methods:
- Retrospective cohort study of 105 gastroschisis patients (2006-2015).
- Exclusion criteria: incomplete data and mortality.
- Successful early enteral feeding defined as full feeding within 21 days of life.
Main Results:
- 53% (n=56) achieved successful early feeding.
- Factors associated with success: female sex (RR=1.38), gestational age >36 weeks (RR=1.23), surgery <10h (RR=1.15), extubation <4 days (RR=1.39), feeding start <10 days (RR=35.69).
Conclusions:
- Several factors influence successful early enteral feeding in gastroschisis.
- Modifiable factors include surgery within 10 hours, extubation within 4 days, and feeding initiation before 10 days.
- Findings can guide gastroschisis management for better outcomes.
Background:
Gastroschisis is the most common congenital abdominal wall defect. Due to the exposure of midgut to amniotic fluid, the recovery of bowel function is often delayed. This study aimed to identify the factors associated with the successful early enteral feeding in gastroschisis and to develop further guidelines of treatment.
Methods:
A retrospective cohort study of gastroschisis babies from January 2006 to December 2015 was done. Exclusion criteria were incomplete data and death. Successful early enteral feeding was defined when full feeding was achieved within 21 days of life.
Results:
One hundred and five gastroschisis patients were divided into a successful early-feeding group (n = 56, 53%) and a non-successful early-feeding group (n = 49, 46%). In multivariable analysis, significant factors for successful feeding clustered by primary treatment were female (RR = 1.38, P value < 0.001), gestational age > 36 weeks (RR = 1.23, P value < 0.001), age at surgery less than 10 h (RR = 1.15, P value < 0.001), postoperative extubation time < 4 days (RR = 1.39, P value < 0.001), and age when feeding started less than 10 days (RR = 35.69, P value < 0.001).
Conclusion:
Several factors were found to be associated with successful early enteral feeding. The modifiable factors found in this study were surgery within 10 h, early postoperative extubation within 4 days, and feeding started before 10 days of life. These will guide the management of gastroschisis to achieve successful early enteral feeding.
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