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Median urinary iodine concentration reflected sufficient iodine supply in neonates from Northeast Germany in

Till Ittermann1, Henry Völzke2, Anne Krey3

  • 1Institute for Community Medicine, University Medicine Greifswald, Walther Rathenau Str. 48, 17475, Greifswald, Germany. till.ittermann@uni-greifswald.de.

European Journal of Nutrition
|May 27, 2018
PubMed

Insights

Neonates in Northeast Germany show sufficient iodine supply, with median urinary iodine concentrations (UIC) of 150 µg/L. This suggests adequate iodine levels may extend to other regions, despite adult studies indicating potential mild deficiency.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Recent adult studies indicate declining urinary iodine concentrations (UIC) in Germany.
  • No German studies have assessed neonatal UIC since 1996.
  • Iodine is crucial for neonatal thyroid hormone synthesis and development.

Purpose of the Study:

  • To investigate urinary iodine concentrations (UIC) in German neonates.
  • To assess serum thyroid-stimulating hormone (TSH) levels in neonates.
  • To determine iodine status in a contemporary German neonatal cohort.

Main Methods:

  • Analysis of urinary iodine concentrations (UIC) in 399 neonates born in Northeast Germany (2005-2006).
  • UIC measurement using a photometric method, corrected for ICP-MS comparability.
  • Serum TSH levels determined from capillary blood samples collected within 5 days of birth.

Main Results:

  • Median UIC was 150 µg/L, higher in boys than girls (p=0.012).
  • 14% of neonates exhibited serum TSH levels > 5 mIU/L.
  • Neonates of mothers with iodine supplementation had higher median UIC (150 µg/L) vs. those without (132 µg/L; p=0.011).
  • A significant association was found between UIC and log-transformed serum TSH levels (p=0.028).

Conclusions:

  • Neonates in Northeast Germany demonstrate a sufficient iodine supply.
  • Findings suggest potentially adequate iodine status in neonates across Germany.
  • This contrasts with some adult studies suggesting mild iodine deficiency in the general population.
Abstract

Keywords:
IodineIodine supplementationNeonatesThyroid-stimulating hormone

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