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The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application

Mengmeng Lu1, Shuaifang Yuan1, Shicheng Li2

  • 1Department of Hypertension, Henan Provincial People's Hospital, Laboratory of Cancer Biomarkers and Liquid Biopsy, Henan University, Kaifeng, Henan Province, 475004, China.

Journal of Cardiovascular Translational Research
|May 27, 2018
PubMed

Insights

Exosomes, tiny vesicles released by cells, show promise as biomarkers for atherosclerosis, a major cardiovascular disease. Their contents like miRNA, protein, and DNA could aid in diagnosis and treatment.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Molecular Biology

Background:

  • Atherosclerosis is a primary cause of global mortality, necessitating novel biomarkers for effective management.
  • Exosomes, cell-derived vesicles, mediate intercellular communication and are implicated in atherosclerosis.
  • These vesicles contain nucleic acids, proteins, and lipids, making them rich sources of potential biomarkers.

Purpose of the Study:

  • To review the potential of exosome-derived components as biomarkers in atherosclerosis.
  • To explore the roles of exosome-derived miRNA, protein, and DNA in pathogenesis, diagnosis, and therapy.

Main Methods:

  • Literature review of studies on exosomes and atherosclerosis.
  • Analysis of exosome content (miRNA, protein, DNA) in relation to disease processes.
  • Synthesis of current knowledge on exosome functions in cardiovascular disease.

Main Results:

  • Exosomes play critical roles in cell-to-cell communication within the context of atherosclerosis.
  • Exosome-derived miRNA, proteins, and DNA are emerging as significant indicators of atherosclerotic development.
  • These components offer potential for early diagnosis and targeted therapeutic strategies.

Conclusions:

  • Exosomes represent a promising frontier for biomarker development in cardiovascular diseases, particularly atherosclerosis.
  • Targeting exosome-derived molecules could lead to improved diagnostic tools and therapeutic interventions for atherosclerosis.
  • Further research into exosome biology is crucial for unlocking their full potential in managing cardiovascular health.

Keywords:
AtherosclerosisBiomarkersCardiovascular diseaseExosomesmiRNA

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