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Related Experiment Video

Updated: Feb 10, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Red Ear: Syndrome or Symptom?

Isabel Loução de Amorim1, Linda Azevedo Kauppila1, Isabel Pavão Martins2

  • 1Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria, CHLN, Lisbon, Portugal.

Headache
|May 27, 2018
PubMed
Summary

Red ear syndrome (RES) involves attacks of unilateral ear pain and redness. New cases suggest RES may be a symptom associated with primary headaches like migraine, rather than a distinct syndrome.

Keywords:
headachemigrainered eartrigemino-autonomicvasodilatation

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Area of Science:

  • Neurology
  • Pain Medicine

Background:

  • Red ear syndrome (RES) is a rare condition with unilateral ear pain and redness.
  • Existing theories link RES to cervical spinal nerve dysfunction and trigemino-autonomic circuit dysregulation.

Observation:

  • Six new cases of RES were analyzed.
  • Patients presented with the characteristic red ear symptom.
  • Headache patterns varied, resembling migraine or cluster headache.

Findings:

  • The cardinal symptom of red ear was present in all cases.
  • Therapeutic responses were linked to treatments for associated primary headaches.
  • This suggests RES might be a phenomenon secondary to other headache disorders.

Implications:

  • RES may not be an independent syndrome but rather a manifestation of other primary headaches.
  • Understanding this association can refine diagnostic and therapeutic strategies for patients with red ear symptoms.
  • Further research is needed to clarify the relationship between RES and various primary headache types.