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Updated: Feb 10, 2026
05:37
Human Internal Mammary Artery IMA Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
Published on: May 9, 2012
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Does mirabegron relieve ureteric stent-related discomfort? A prospective, randomized, multicentre study
Bum Sik Tae1, Seok Cho2, Byung Jo Jeon1
1Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
BJU International
|May 27, 2018
Summary
Mirabegron significantly reduced ureteric stent-related pain in patients undergoing ureteroscopic procedures. This medication shows potential for managing stent discomfort, warranting further investigation in larger trials.
Area of Science:
- Urology
- Pharmacology
Background:
- Ureteric stents are commonly used after ureteroscopic procedures.
- Stent-related discomfort significantly impacts patient quality of life.
Purpose of the Study:
- To evaluate the efficacy of mirabegron in alleviating ureteric stent-related discomfort.
- To assess the impact of mirabegron on pain, urinary symptoms, and general health post-ureteroscopy.
Main Methods:
- A multicentre randomized study involving 96 patients with ureteric stents.
- Patients received either 50 mg mirabegron once daily or no treatment.
- Outcomes were assessed using the Ureteral Stent Symptom Questionnaire (USSQ) and International Prostate Symptom Score (IPSS).
Main Results:
- Mirabegron significantly reduced USSQ body pain and overall pain scores compared to the control group (P=0.007 and P=0.002, respectively).
- A significant reduction in IPSS storage symptom score was observed in the mirabegron group (P=0.035).
- No significant differences were found in USSQ urinary symptom scores, general health scores, or post-void residual urine volume.
Conclusions:
- Daily administration of 50 mg mirabegron shows potential in reducing ureteric stent-related pain and discomfort.
- Further large-scale, placebo-controlled studies are recommended to confirm these findings and explore mirabegron's benefits for stent-related symptoms.
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