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Maximising success in multidrug formulation development: A review.

Oisin N Kavanagh1, Ahmad B Albadarin1, Denise M Croker1

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Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 27, 2018
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Multidrug formulations (MDFs) are crucial for improving patient compliance in healthcare. This review explores MDF challenges, solutions, and strategies for clinical translation to enhance patient outcomes.

Keywords:
Drug delivery and drug developmentFixed dose combinationMultidrug deliveryPatient compliancePolyPill

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Healthcare Management

Background:

  • Increasing chronic disease prevalence and an aging population are straining healthcare systems.
  • Current patient compliance strategies are insufficient to meet growing demands.
  • Multidrug formulations (MDFs) offer a promising approach to address these challenges.

Purpose of the Study:

  • To summarize challenges and solutions in designing Multidrug Formulations (MDFs).
  • To review current and emerging MDF strategies and their clinical translation.
  • To identify research gaps for future MDF development.

Main Methods:

  • Literature review of MDF development and formulation science.
  • Analysis of scientific novelty versus clinical impact in MDF research.
  • Discussion of strategies for benchtop to clinic translation.

Main Results:

  • Key challenges in MDF design and formulation have been identified.
  • Successful MDF strategies and their scientific rationale are presented.
  • Examples of novel MDFs with limited clinical appreciation are highlighted.

Conclusions:

  • MDFs present a viable strategy to improve patient compliance and manage chronic conditions.
  • Bridging the gap between scientific innovation and clinical application is essential for MDF success.
  • Further research into modernized MDF approaches is needed to maximize patient impact.