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Prophylactic Bevacizumab May Mitigate Radiation Injury: An Experimental Study
Ayfer Aslan1, Zeynep Bengisu Kaya2, Erkut Baha Bulduk1
1Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.
World Neurosurgery
|May 27, 2018
Summary
Prophylactic bevacizumab delays radiation necrosis after stereotactic radiosurgery (SRS) in rats. This anti-VEGF antibody mitigated injury, unlike delayed treatment, showing timing is crucial for managing SRS side effects.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Stereotactic radiosurgery (SRS) treats brain pathologies but can cause radiation injury.
- Radiation injury, marked by edema and necrosis, necessitates management strategies.
- Bevacizumab, an anti-VEGF antibody, is a potential agent targeting radiation injury.
Purpose of the Study:
- To investigate the effects of SRS and bevacizumab in a rat model.
- To compare prophylactic versus delayed bevacizumab treatment following SRS.
- To analyze radiation injury and its management with bevacizumab.
Main Methods:
- Fifty-four Wistar rats were divided into 9 groups with varying Gamma-knife surgery (GKS) doses and bevacizumab protocols.
- Right frontal lobes were analyzed after 12 weeks using H&E staining and immunohistochemistry (VEGF, CD31).
- Evaluated radiation necrosis onset, degree, and bevacizumab's mitigating effects.
Main Results:
- Radiation necrosis developed in all irradiated rats between 3-10 weeks post-SRS.
- Higher GKS doses accelerated necrosis; prophylactic bevacizumab delayed its onset.
- Prophylactic bevacizumab mitigated SRS-induced radiation necrosis, while delayed treatment showed less effect.
Conclusions:
- GKS dose and bevacizumab administration timing significantly impact radiation injury.
- Prophylactic bevacizumab is effective in mitigating SRS-induced radiation necrosis.
- The study highlights the importance of treatment protocol in managing SRS side effects.
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