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Formulation and stability of iopentol
K Skinnemoen1, R Fagervoll, L Aanstad
1Analytical Chemistry Department, Nycomed AS, Oslo, Norway.
Acta Radiologica. Supplementum
|January 1, 1987
Abstract:
The autoclaving studies which were performed to develop a formulation of iopentol are presented. The same formulation as used for iohexol was found to be suitable for iopentol. It was shown that it is essential to use a buffer such as trometamol to lower the pH during autoclaving in order to achieve a low level of deiodination after autoclaving. Results from the on-going stability studies indicate a good stability of iopentol finished product.