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Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia
Shahrokh Mehrpisheh1, Azadeh Memarian2, Abolfazl Mahyar3
1Department of Neonatology, Mazandaran University of Medical Sciences, Mazandaran, Iran.
BMC Pediatrics
|May 28, 2018
Summary
This study found no significant link between vitamin D levels and neonatal indirect hyperbilirubinemia (NIH). Further research is needed to confirm vitamin D
Area of Science:
- Neonatology
- Endocrinology
- Pediatrics
Background:
- Neonatal indirect hyperbilirubinemia (NIH) is prevalent and can cause irreversible neurological damage.
- Identifying factors contributing to neonatal jaundice is crucial for prevention and management.
- Vitamin D deficiency is a growing concern in infant populations.
Purpose of the Study:
- To investigate the association between serum vitamin D levels and the incidence of NIH.
- To compare vitamin D status in infants with and without NIH.
Main Methods:
- A case-control study involving 30 term infants with NIH and 30 healthy term infants.
- Serum 25-hydroxyvitamin D levels were measured and compared between groups.
- Statistical analysis included t-tests and Chi-square tests.
Main Results:
- Mean serum 25-hydroxyvitamin D levels were 10.76 ± 8.6 ng/dL in the NIH group and 14.88 ± 11.38 ng/dL in the control group.
- No statistically significant difference in vitamin D levels was observed between the case and control groups (P = 0.11).
Conclusions:
- Current findings suggest no direct relationship between vitamin D levels and NIH.
- Further prospective studies are recommended to definitively ascertain vitamin D's role in NIH pathogenesis.
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