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Comparative evaluation of powder flow parameters with reference to particle size and shape
Hui Ping Goh1, Paul Wan Sia Heng1, Celine Valeria Liew1
1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
International Journal of Pharmaceutics
|May 28, 2018
Summary
Understanding powder flow in pharmaceuticals is key. This study links flow parameters to physical properties like cohesion and friction, revealing how granule size and shape influence pharmaceutical powder behavior.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Chemical Engineering
Background:
- Powder flow is crucial for pharmaceutical manufacturing processes like tableting and capsule filling.
- Existing powder flow characterization methods and parameters lack established inter-relationships and clear links to physical properties.
- The specific impact of particle size and shape on individual flow parameters remains poorly understood.
Purpose of the Study:
- To investigate the inter-relationships between various powder flow parameters.
- To classify flow parameters based on underlying physical granule properties using multivariate analysis.
- To elucidate the relative impact of particle size and shape on powder flow characteristics.
Main Methods:
- Granules were characterized for their flow properties using multiple techniques.
- Multivariate analysis was employed to correlate flow parameters with physical granule attributes.
- Key physical properties investigated included cohesion, compressibility, inter-particulate friction, particle size, and shape.
Main Results:
- Powder cohesion, influenced by the smallest granule size fraction, primarily affects angle of repose, Hausner ratio, shear cell parameters, and avalanche flow.
- Powder compressibility and inter-particulate friction are the main drivers of basic flow energy.
- Particle roundness significantly impacts the angle of internal friction, which does not appear to reflect bulk powder flow properties.
Conclusions:
- Different powder flow characterization techniques measure distinct aspects, but common physical attributes govern their outcomes.
- Granule size distribution, particularly the finest fraction, is a critical determinant of powder cohesion and subsequent flowability.
- Particle shape, specifically roundness, influences inter-particulate friction and internal friction angle, with varying relevance to bulk flow behavior.
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