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Development of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung delivery

Dina M Silva1, Roberto Paleco2, Daniela Traini2

  • 1School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia.

International Journal of Pharmaceutics
|May 28, 2018
PubMed

Insights

This study developed inhalable ciprofloxacin-loaded poly(vinyl alcohol) microparticles for sustained lung drug delivery. The optimized microparticles demonstrated high encapsulation efficiency and improved aerodynamic properties for antibiotic treatment.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Polymeric microparticles serve as advanced carriers for sustained lung drug delivery.
  • They offer an alternative to traditional excipients in pulmonary drug formulations.

Purpose of the Study:

  • To develop and characterize inhalable ciprofloxacin (CPx)-loaded poly(vinyl alcohol) (PVA) microparticles.
  • To optimize processing parameters for effective drug encapsulation and suitable aerodynamic properties for inhalation.

Main Methods:

  • Single-step spray-drying technique was employed for microparticle fabrication.
  • Orthogonal experimental design was used to optimize polymer concentration, feed rate, and inlet temperature.
  • Fourier transformed infrared spectroscopy, differential scanning calorimetry, and next-generation impactor were utilized for characterization and aerodynamic assessment.

Main Results:

  • Spray-dried PVA-CPx microparticles achieved over 90% drug encapsulation efficiency.
  • Formulations exhibited suitable morphology and size for inhalation, with sustained drug release over 24 hours.
  • Aerodynamic assessment showed improved mass median aerodynamic diameter (5.06±0.10μm) and fine particle fraction (39.78±0.98%) compared to CPx alone.

Conclusions:

  • Spray-dried poly(vinyl alcohol) microparticles are effective carriers for sustained lung delivery of ciprofloxacin.
  • These microparticles hold significant potential for local antibiotic delivery in the lungs, improving therapeutic outcomes.
Keywords:
Drug deliveryLung administrationNext generation impactorPoly(vinyl alcohol)Spray-drying

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