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Related Experiment Video

Updated: Feb 10, 2026

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels
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Cartilage diseases.

Yamini Krishnan1, Alan J Grodzinsky2

  • 1Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

Matrix Biology : Journal of the International Society for Matrix Biology
|May 28, 2018
PubMed
Summary

Cartilage diseases significantly impact the extracellular matrix (ECM), affecting joint health and causing conditions like osteoarthritis. This review covers clinical features, treatments, and emerging therapies for cartilage disorders.

Keywords:
CartilageCartilage ECM-targeted drug carriersChondrocalcinosisDiseases of cartilageExtracellular matrixGenetic disorders involving cartilageGrowth plate fracturesInflammatory arthropathiesOsteoarthritisOsteochondritis dissecansPost-traumatic osteoarthritisPseudogout cartilaginous tumorsRelapsing polychondritis

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Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Cell Biology

Background:

  • Cartilage, including hyaline, fibrocartilage, and elastic types, is crucial for load-bearing, joint lubrication, and structural support.
  • Cartilage extracellular matrix (ECM) integrity is vital for normal function; diseases often involve ECM degradation, impacting progression and symptoms.

Purpose of the Study:

  • To provide a comprehensive overview of clinical and pathological features of cartilage diseases.
  • To review current treatment options and highlight recent advances in disease-modifying drug development for cartilage conditions.

Main Methods:

  • This narrative review synthesizes existing literature on cartilage diseases.
  • It examines clinical presentations, pathological mechanisms, and therapeutic strategies.

Main Results:

  • Cartilage diseases manifest with diverse clinical and pathological features, often linked to ECM alterations.
  • Current treatments face challenges due to cartilage's aneural and avascular nature, necessitating innovative drug delivery and disease-modifying approaches.

Conclusions:

  • Understanding cartilage ECM is key to managing diseases like osteoarthritis.
  • Advances in drug development and delivery hold promise for treating widespread cartilage disorders.