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Updated: Feb 10, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
A case of Takotsubo syndrome during a multiple sclerosis brainstem relapse
Elio Prestipino1, Martina Squitieri1, Lorenzo Razzolini1
1University of Florence, NUEROFARBA Department, Neuroscience section, Viale Pieraccini 6, 50139, Florence, Italy.
Background:
We report a case of a woman affected by relapsing remitting Multiple Sclerosis who developed acute left ventricular dysfunction in the context of a severe brainstem relapse, one month after an attempt of in-vitro fertilization.
Discussion:
The characteristics of our case are consistent with the hypothesis of a possible causal association between an acute medulla oblongata lesion and the occurrence of Takotsubo cardiomyopathy.
Conclusion:
Our case adds to previous reports in this field and calls for awareness of this exceptional extra-neurological manifestation of MS. It seems also to confirm the possible association between MS relapses and ovarian stimulation.
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