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Thyroid Ultrasound: More Sensitive than Radioactive Iodine Imaging in Detecting Recurrence of Papillary Thyroid

Brittany K Wise-Oringer1, Marina Goldis2, Molly O Regelmann3

  • 1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Hormone Research in Paediatrics
|May 28, 2018
PubMed

Insights

Neck ultrasound (US) is superior to diagnostic whole-body radioactive iodine scans (DxWBS) for detecting papillary thyroid cancer (PTC) recurrence in children. This imaging technique aids in identifying metastases missed by other methods.

Area of Science:

  • Pediatric Endocrinology
  • Oncology
  • Radiology

Background:

  • Papillary thyroid cancer (PTC) is rare in children but generally has a good prognosis.
  • Traditional surveillance for PTC recurrence includes neck ultrasound (US), thyroglobulin (Tg) levels, and diagnostic whole-body radioactive iodine scans (DxWBS).

Observation:

  • Two pediatric patients with metastatic PTC underwent standard follow-up after treatment.
  • Surveillance included neck US, serum Tg levels, and periodic DxWBS.

Findings:

  • Neck ultrasound successfully identified recurrent and metastatic PTC.
  • Diagnostic whole-body radioactive iodine scans failed to detect these recurrences.

Implications:

  • Neck US demonstrated superior efficacy compared to DxWBS in detecting PTC recurrence in pediatric patients.
  • These findings support the use of neck US as the preferred imaging modality for pediatric PTC surveillance, aligning with American Thyroid Association (ATA) guidelines for detecting local recurrence and lymph node metastases.
Abstract

Keywords:
Pediatric endocrinologyPediatricsThyroglobulinThyroid cancerThyroid ultrasonographyUltrasonography

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