Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.9K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.9K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.1K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.1K
Heart Valves01:16

Heart Valves

12.3K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.3K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

17.7K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
17.7K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

23.4K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.4K
Microbial Morphologies01:29

Microbial Morphologies

3.8K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates.

Lab on a chip·2026
Same author

Lymph Node Dissection and Radiation in the Rat Popliteal Region Leads to Progressive Lymphatic Pump Failure and Lymphedema.

bioRxiv : the preprint server for biology·2026
Same author

Mesoscale Modeling of Hydrogels Under Frictional Shear Stress.

Macromolecules·2026
Same author

Hybrid microneedle patch for administration of measles and rubella vaccine with an on-patient medical record.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury.

ACS nano·2025
Same author

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node.

Nature communications·2025

Related Experiment Video

Updated: Feb 10, 2026

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
13:58

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics

Published on: September 28, 2016

12.3K

Probing the effect of morphology on lymphatic valve dynamic function.

Matthew Ballard1, Ki T Wolf2, Zhanna Nepiyushchikh2,3

  • 1Department of Mechanical Engineering, Saint Martin's University, Lacey, WA, 98503, USA.

Biomechanics and Modeling in Mechanobiology
|May 28, 2018
PubMed
Summary

This study models lymphatic valve mechanics, revealing that optimal function depends on low aspect ratio and bending stiffness. Abnormal valve morphology in lymphatic dysfunction, like lymphedema, can impair pumping performance.

Keywords:
BiomechanicsComputational simulationsLymph transportLymphatic valveLymphedema

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.4K
Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

9.5K

Related Experiment Videos

Last Updated: Feb 10, 2026

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
13:58

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics

Published on: September 28, 2016

12.3K
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.4K
Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

9.5K

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Computational Biology

Background:

  • The lymphatic system is crucial for fluid balance and immunity, yet lymphatic dysfunction mechanisms remain unclear.
  • Lymphatic valves are key to unidirectional lymph flow, but their role in pathologies like lymphedema is poorly understood.

Purpose of the Study:

  • To computationally model lymphatic valve mechanics and their impact on lymphatic system function.
  • To investigate how variations in valve geometry and material properties affect lymph transport and backflow prevention.

Main Methods:

  • Developed a 3D computational model coupling fluid (Lattice Boltzmann) and solid (Lattice Spring) mechanics.
  • Simulated lymph flow and valve dynamics under various geometric and mechanical conditions.

Main Results:

  • Lymphatic valve function is optimized with low aspect ratio and bending stiffness, provided proper closure is maintained.
  • Valve stiffening significantly impacts lymphatic pumping performance.
  • The model accurately captures the dynamic response of valves to flow conditions.

Conclusions:

  • Valve morphology and mechanics are critical determinants of lymphatic function.
  • Abnormal valve characteristics, as seen in primary lymphedema, can lead to significant lymphatic dysfunction.
  • This model provides insights into the biomechanical basis of lymphatic pathologies.